In this study, mature sweet orange fruits (amber variety) were separately subjected to hot water treatments: 35 o C for 25 and 30 minutes; 45 o C for 15, 20 and 25 minutes; 48 o C for 10, 15 and 20 minutes; 50 o C for 10, 15 and 20 minutes; 53 o C for 10 minutes and 55 o C for 5 minutes and were thereafter assessed for their DNA quality while unheated fruits served as control. The DNA quality was done by rapid random polymorphic DNA-polymersae chain reaction (RAPD-PCR) on the extracted DNA from each set of treated fruits using the RAPD primer OPR 02 (5’ – CAC AGC TGC C-3’).
NIH Funded Articles
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- Predictors of Obstructive Sleep Apnea Risk among Blacks with Metabolic Syndrome
- Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study
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Comparative Study for Efficacy and Safety of Biosimilar Infliximab in Patients with Active Rheumatoid Arthritis on a stable Dose of Methotrexate
The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.
A granular cell tumor of the breast parenchyma is a rare tumor accounting for 5-6% of all granular cell carcinoma and are mostly benign in nature.
Nonparametric estimation of cumulative cause specific reversed hazard rates under masked causes of failure
In the analysis of competing risks data, it is common that the exact cause of failure for certain study subjects is missing. This problem of missing failure type may be due to inadequacy in the diagnostic mechanism or reluctance to report the exact cause of failure.